Abstract The induction of antiviral innate immunity by systemic immunization with live virus can be employed to positively impact the response to therapeutic vaccination.We previously demonstrated that systemic immunization with a non-replicating MVA encoding CD40 ligand (CD40L) enhances innate immune cell activation and function, and triggers pote
It is known that total telomere length is shorter in invasive breast cancer than in normal breast tissue but the status of individual telomere lengths has not been studied.Part of the difficulty is that usually telomere length in interphase cells is measured on all chromosomes together.In this study we compared normal breast epithelium, duct doctor
Increasingly, ethical concepts ordinarily reserved for the human research setting have been applied to nonhuman animals in research.This comes at the same time as concerns mount andre 3000 new blue sun zip over challenges in translating the results of biomedical research with animals to human clinical benefit.This paper argues that applying the con
Preclinical studies suggest the beast sullivan supply that fasting prior to chemotherapy may be an effective strategy to protect patients against the adverse effects of chemo-toxicity.Fasting may also sensitize cancer cells to chemotherapy.It is further suggested that fasting may similarly augment the efficacy of oncolytic viral therapy.The primary
Double-bundle (DB) anterior cruciate ligament (ACL) reconstruction has biomechanical advantages over single-bundle reconstruction.However, most studies perform the DB reconstruction with 2 femoral tunnels, which fails to provide an entire femoral footprint for ACL reconstruction.In this study, we describe a femoral double-bundle footprint technique